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Birth defects or genetic abnormalities in infants conceived after letrozole or clomid therapy. In fact, there were significantly fewer heart problems in the letrozole group compared to the clomid group! In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects. Letrozole caused embryo-fetal toxicities in rats and rabbits at maternal exposures that were below the maximum recommended human dose (mhrd) on a mg/m 2 basis. Advise pregnant women of the potential risk to a fetus. Clomiphene has been used for over 40 years without any evidence of an increased risk of birth defects. It is unclear whether clomiphene could increase the risk of ovarian cancer or breast cancer – as a precaution most experts recommend that clomiphene should not be used for more than twelve months. Whether letrozole will cause more birth defects than other drugs isn't known, legro said
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4%) out of 514 conceived with letrozole were found to have congenital malformations and chromosomal abnormalities, and 19 (4, 8%) out of 397 newborns in the clomid group, which appears to have double negative effect. The studies related to the use of letrozole for ovulation treatment and risk of fetal anomalies are all very reassuring and those large studies do not show an increased risk of birth defects when letrozole is used to induce ovulation. Cipla letrozole can induce harm to the unborn baby and should not be used in pregnant women. In post-marketing reports, the use of cipla letrozole during pregnancy resulted in problems of unintentional abortions and existing birth defects. Pregnant women are advised of the possible risk to an unborn baby. Femara (letrozole) has been approved by the fda to treat breast cancer in post-menopausal women. But, many doctors also prescribe the drug as an infertility treatment, a non-approved use, despite the known risks of birth defects and miscarriages. And is contraindicated for use in pregnant women. In post-marketing reports, use of letrozole during pregnancy resulted in cases of spontaneous abortions and congenital birth defects. Letrozole caused embryo-fetal toxicities in rats and rabbits at maternal exposures that were below the maximum recommended human dose (mhrd) on a mg/m2 basis. Results:overall, congenital malformations and chromosomal abnormalities were found in 14 of 514 newborns in the letrozole group (2. 4%) and in 19 of 397 newborns in the cc group (4. The major malformation rate in the letrozole group was 1. 2% (6/514) and in the cc group was 3. Tracking birth defects the study included 150 babies born to women who had taken femara for fertility. The women had been treated at the montreal fertility centre, where biljan works. Researchers were particularly interested in comparing two common drugs that promote extra egg release to a newer treatment using an aromatase inhibitor called letrozole, which has shown promising. Letrozole may increase the risk of birth defects if taken when pregnant. Therefore, all patients need a blood draw to check b-hcg and progesterone levels prior to starting the medication. The use of letrozole prior to pregnancy (as utilized for ovulation induction) has also been studied to evaluate the risk of birth defects. Whether letrozole will cause more birth defects than other drugs isn't known, legro said. Polycystic ovary syndrome (pcos) is a common cause of anovulatory infertility. Optimal ovulation induction would achieve ovulation and live birth while minimizing the risk of multiple gestations, birth defects, side-effects, and cost. The optimal first-line agent has evolved based on several notable randomized controlled trials with surprising results
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